Founded in 1995, InCube Ventures invests in life sciences ventures across the US. InCube identifies extraordinary innovations that solve unmet clinical needs for large patient populations, and help bring those innovations to market. InCube Ventures is the venture arm of InCube Labs, a research and development lab located in Silicon Valley and San Antonio. InCube Ventures has multiple funds including its first fund, DFJ InCube Ventures, managed with Draper Fisher Jurvetson.

Notable investments include: Body Media (acquired by Jawbone), Channel Medsystems, Fe3 Medical, Neurolink, Rani Therapeutics, Sonoma Orthopaedics and Spinal Modulation.