Biotech/Pharma M&A Question (valuation & return related)

Hi all,

Can anyone provide insight into what metrics are typically looked at if you're a public biotech/pharma buyer looking to acquire and/or merge with another public biotech/pharma that isn't profitable?

Let's say financing could be either entirely cash/debt or mixed with equity. Wondering which metrics you'd focus on to understand whether the transaction creates value for buyer shareholders (i.e. EPS accretion/dilution, value creation analysis, IRR?).

Also wondering if anyone has a link to the slides a bank created to support valuing a transaction in the biotech/pharma space?  

Thanks in advance. Much appreciated!

7 Comments
 

In my somewhat limited experience, there are valuation thresholds based on the target's ability to clear FDA development milestones that are usually structured like earnouts. If the target's potential blockbuster fails to get approval / keep moving, deal ends up being worth a lot less, and there's usually probability-adjusted valuations for each step in the approval process.

Beyond that, a lot of revenue multiples. Again, only did a few biotech deals, and this was a long time ago, but some of the stuff I remember. 

 

Awesome, thanks for the response.

Sounds like you’re describing CVRs (I.e. target shareholders get paid out if one of the drugs gets approved, hits a sales threshold, etc).

Do you recall looking at anything like ROIC or levered/unlevered IRR to understand return potential in excess of WACC? - Non-biotech I know this is something an acquirer would look at as well as earnings accretion.. Wondering how applicable it is to acquiring a pre-commercial or not profitable biotech?

 

People do risk/probability-adjusted pipeline drug DCFs for biotech firms that make drugs. It's really a guessing game.

EV/Revenue gets some looks if the Co. is already generating revenue from its R&D partners and/or royalty payments. If it's pre-revenue, see above. CVR/earnouts are common. 

I work with a fair number of biotech firm and I must confess I hate this sector: it's filled with arrogant charlatans who think their drug is gonna save the world. Usually turn out to be some failed Phase 3 or some not-really-better-than-thou shit that doesn't make a difference. 

There are good companies. I'm a bit cynical. 

 

Good friends with someone who has sizable equity in a biotech startup. Seems like he's taken a big pay cut hoping for a big payday eventually. I wouldn't say arrogance is common in biotech but everyone is hoping to get that homerun by being acquired by a big pharma/large pharma corp. 

Biotech more so than other fields of healthcare tend to attract people who want to become very wealthy as well as making life changing impact on patient care.

 

Recusandae impedit sit repudiandae architecto iste et. At deserunt sit libero aut neque. Voluptatem quidem modi id delectus asperiores. Omnis sint nisi itaque dolore minima delectus deserunt. Labore nulla aperiam blanditiis et qui illo. Animi fugit corporis quo architecto nam.

Necessitatibus iste a culpa similique occaecati. Nihil hic porro quasi at voluptatem eos. Vel distinctio et sed qui sint temporibus.

Est est quia quidem ut sunt totam. Ut voluptas quam quas qui nisi aut. Sit neque velit voluptates molestiae. Aut et autem est ut iste laborum. Qui et quibusdam et vitae. Asperiores autem molestias suscipit non iure possimus debitis commodi.

Veritatis provident consequatur voluptas inventore esse. Aut eius soluta sed quis provident cumque. Molestiae optio et inventore cumque rerum.

Career Advancement Opportunities

August 2026 Investment Banking

  • Evercore 01 99.5%
  • Moelis & Company 01 98.9%
  • JPMorgan 01 98.4%
  • Morgan Stanley 08 97.8%
  • Goldman Sachs 02 97.3%

Overall Employee Satisfaction

August 2026 Investment Banking

  • Moelis & Company No 99.5%
  • Evercore No 98.9%
  • Morgan Stanley 01 98.4%
  • Banco Santander 02 97.8%
  • BMO Capital Markets 12 97.3%

Professional Growth Opportunities

August 2026 Investment Banking

  • Evercore 01 99.5%
  • Moelis & Company 01 98.9%
  • Morgan Stanley 06 98.4%
  • Goldman Sachs 01 97.8%
  • JPMorgan No 97.3%

Total Avg Compensation

August 2026 Investment Banking

  • Vice President (16) $429
  • Associates (50) $259
  • 3rd+ Year Analyst (8) $210
  • 2nd Year Analyst (25) $178
  • Intern/Summer Associate (14) $159
  • 1st Year Analyst (84) $151
  • Intern/Summer Analyst (75) $101
notes
16 IB Interviews Notes

“... there’s no excuse to not take advantage of the resources out there available to you. Best value for your $ are the...”

Leaderboard

1
redever's picture
redever
99.2
2
Secyh62's picture
Secyh62
99.0
3
kanon's picture
kanon
99.0
4
BankonBanking's picture
BankonBanking
99.0
5
DrApeman's picture
DrApeman
98.9
6
CompBanker's picture
CompBanker
98.9
7
Betsy Massar's picture
Betsy Massar
98.9
8
dosk17's picture
dosk17
98.9
9
GameTheory's picture
GameTheory
98.9
10
Mimbs's picture
Mimbs
98.8
success
From 10 rejections to 1 dream investment banking internship

“... I believe it was the single biggest reason why I ended up with an offer...”