For a pharmaceutical company raising funds, are middle market investment banks a good source of finance?

This is a odd question, but I know this forum has a lot of people who work in investment banking

I and my 2 of colleagues have recently started a startup pharmaceutical company that has identified 3 derisked drugs to bring to market that would have a massive return overall. We would raise a initial small capital to get some regulatory approvals then go to a PE fund to raise capital for the trial.

FYI, we are all MDs (physicians) by background and one of us has previously worked for a biotech as chief of staff to bring a drug to phase III. We are still in our 20s.

Naturally, as we try to raise capital, we hit a bit of a weird bump because unlike most startup that can slowly grow. These oppertunities we identified is straight up capital intensive and there isn't much traction we can show asides having the assets and some regulatory plans with us which we already have. Our data room is pretty solid.

Whilst, we could raise capital from VCs most of them aren't really interested in single asset opportunities to flip if that makes sense. Or at least that's what my few limited conversations have led me to believe. They are looking for the unicorn type companies which stay generational.

We recently started to outreach a few middle market IB in the US, trying to see if this might be of interest to them to sell to their network (ie family offices, HNI etc). We have a meeting with one, but would love to hear those who work in this space -

1) Do you think investment banks are useful players for us to approach?

2) We will initially raise $3m to $5m and then later go for a larger raise ($50m per asset) for the trial itself- what would be the middle market IB fees for this roughly?

Does the above strategy seem sensible?

3) Is there alternative options of raising finance for a attractive return that would fund a specialist one off oppertunity like this? - (FYI we found that since biotech is very niche not many traditional investors have much experience in investing in biotech space

3 Comments
 

Based on the most helpful WSO content, here’s what you need to know:

  1. Are middle market investment banks (IBs) useful players for your approach?

    • Middle market IBs can indeed be a viable option for raising funds, especially for niche opportunities like biotech and pharmaceuticals. These banks often have strong networks with family offices, high-net-worth individuals (HNIs), and specialized investors who may be interested in high-risk, high-reward opportunities. However, keep in mind that biotech is a highly specialized field, and many investors in this space prefer to work with funds or advisors who have deep expertise in the sector. Your solid data room and regulatory plans will be key in convincing them of the opportunity.
  2. Middle market IB fees for your raise:

    • For a smaller raise like $3M to $5M, middle market IBs typically charge a success fee in the range of 5-10% of the capital raised. For larger raises like $50M, the fee percentage may decrease slightly, but the absolute fee will still be significant. Additionally, there may be retainer fees (monthly fees paid upfront) during the process, which can range from $25K to $100K+, depending on the bank and the complexity of the deal. Make sure to negotiate these terms upfront and ensure alignment on expectations.
  3. Alternative options for raising finance:

    • Since traditional VCs may not be interested in single-asset opportunities, here are some alternative routes:
      • Specialized Biotech VCs: Funds like Atlas Venture, Third Rock, 5AM Ventures, Flagship, Orbimed, and Versant are known for leading Series A deals in biotech. These firms often focus on early-stage biotech opportunities and may be more open to single-asset plays if the science and regulatory pathway are compelling.
      • Crossover Funds: Hedge funds or mutual funds that invest in late-stage private rounds and anchor IPOs could be an option for your larger raise. These groups often hire PhDs and have a deep understanding of biotech investments.
      • Family Offices and HNIs: These investors may be more flexible and willing to take on niche opportunities. Middle market IBs can help connect you to these networks.
      • Strategic Partnerships: Partnering with larger pharmaceutical companies or sponsor-backed strategics could provide funding and expertise. These players often look for innovative assets to add to their pipelines.
      • Direct Lending or Debt Financing: While less common in biotech, some direct lending funds or private credit firms might be willing to structure a deal if the assets are sufficiently de-risked.

Your strategy of raising an initial smaller round for regulatory approvals and then pursuing a larger raise for trials seems logical. However, the key will be to clearly articulate the value proposition, risk mitigation, and potential returns to investors. Networking with specialized biotech investors and leveraging your team's MD background and prior experience will also be critical in building credibility.

Sources: Healthcare / Biotech Venture Capital?, Biotech finance: from IB to VC / HF to funded startup, Top Venture Capitals that hire juniors?

I'm an AI bot trained on the most helpful WSO content across 17+ years.
 

Starting a company like this would be a dream for me congrats and best of luck.

If I were you and needed funding that size, I would be reaching out to angel investors / VCs that could go for a seed that would get me to the IND. If you’re in the Bay Area or Boston there’s a few lab / accelerators out there which have events to meet sources of capital / people who have the same problem.

Unless you have a strong connection with an MD at a bank, I don’t think anyone will move their feet for you at that size. I work at a bulge not MM if someone thinks differently please correct me.

 

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