Mod Note (Andy): This post was originally a comment on eb ft but..
Son, I am going to get you laid in spite of yourself. I have been waiting for a way to give back and pay it forward so to speak and I do believe this is that opportunity.
FIRST your appearance.
If you are out shape, hit the gym. Next get a, clean and tight (preferably one that you can style your hair). Unless you've got amazing locks, at which point let em' hang loose. Also get your barber to do your eyebrows, trust me they probably need it. And check your nose. Trim and clean your nails, floss your teeth, SHAVE it's ok to have scruff but your neck must be clean shaven. Smell good but don't overdo it if you decide to use cologne (one spray center chest, no more, no less). Women notice every detail.
Clothes. Dress shirts, think Hugo Boss, Brooks Brothers (see that post by @Going Concern on "going out clothing"), sleeves will be rolled three times so they sit below your elbow roughly 80% of the way up your forearm. Jeans that fit well, Levis 501, Lucky Brand, whatever but they need to fit well! Dress shoes -- lighter brown, you'll get more use out of them. Get a watch, you don't need awatch, just get a leather band watch and a metal watch that look good. Be sure to always iron your dress shirts before heading out.
Now your look should be on lock, by the way I know a guy who is about 50lbs overweight who will pull more pussy than you can possibly imagine, so don't fret if you are out of shape. If you are a bean pole, eat some hamburgers, no girl wants a guy whose ass she could kick. Work on your posture when you walk and stand. Hands are never in your pockets.
Break. Even as an executive summary that is a lot of information to take in.
Start talking to people. I mean from the people in line at the library to the librarian. Start talking to people and getting comfortable approaching and starting conversations out of thin air. Even if you think you are solid, do it. You want to work on situational humor because the material is potentially limitless and perfect for any given situation. Work your jokes on guys, then unattractive girls, then medium girls, then hotter girls. At the point when you are talking to a hot girl it's like talking to that ugly librarian.
When you start going to get numbers and making approaches, you are going to just get rejected, over and over again. But it takes the sting out of it the more you do it and you'll start to see what does and does not work. Most importantly, if for even a second you have any doubts about a girl or she doesn't seem 85-100% interested in you. Delete the number and move on. Do NOT get hung up on time sinks.
Now at the club, your best bet is when everyone gets flushed out onto the street around closing time or in line on your way in. Seen and be seen applies, you want to look like you are having fun. Do not hesitate when you see a girl you want to talk to. Be mindful of the optics, so if girls are looking at you walking across the whole club and you get effectively shut down that isn't good. Conversely if you get a girls number, her or her friends are going to have their eyes on you, so be sure to be out of sight when getting another number or just hop to the next bar/club.
It gets easier with time.
Leverage your friends, their girlfriends, BBQs, events, everything. Do not read any of the pick up bullshit. You can make friends easily, it is also better to just show up and say your hellos, get a number or two and then bounce. Rather than actually sticking around and partying. College is pretty easy because most girls just want to get ripped. Should be a decent starting point and if all of that fails let us know.