Street bullish, investor sentiment negative?

What drives wide dispersion between sell-side sentiment and buy-side sentiment?

Normally the sell-side price chases and re-rates stocks based on price vol. but occasionally I come across a stock that the street is crazy about ie. 50% upside target (avg. consensus) that isn't a commodity play but a growth story and investor sentiment will run completely counter... Anyone have an explanation for this? Also, there is almost NO short interest in the stock, just longs selling...