When Should You Cash Out of the Market

Investing professionals - when, if ever, do you cash out of your brokerage portfolio?

Obviously I am investing for the long term like many others, but say after 5 years, your portfolio has grown around $200k - would it be wise to cash out like $50k and spend it? $150k in the portfolio at 26 isn't bad right? Plus I have many years to continue adding to the portfolio.

Thanks everyone.

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