Calculating P/E ratio with negative EPS

Hi WSO,

I'm in need of some accounting/financial advice. If I'm calculating the P/E ratio for a series of pre-revenue biotechs and many of them have a negative EPS, can it still be done?

I would end up with a negative P/E ratio which I know is not great, but if all of the companies analysed result in negative P/E ratios can I still make comparisons?

The underlying theme is to understand if companies with certain characteristics are over or under valued on the stock market. Would also be happy to hear thoughts on using ratios other than P/E. Am also considering Earnings Yield and P/E - Growth ratios.

Cheers

14 Comments
 

Maybe you can use a forward multiple with positive earnings projections?

Also perhaps in this case it might be best to value the company through a different approach like EV/Revenue, EV/EBIT, or even something like a precedent transaction analysis for a ceiling and an asset cost approach for a floor?

STONKS
 

Negative ratios are useless. When the companies get closer to break even, the multiple get more negative and when it switches to positive it suddenly becomes a high positive number: no predictive value.

For pre-revenue biotechs you should value the pipeline, basically a DCF with probability of succesful tests/approval/etc. often with an exit to large strategic after that phase.

 
Most Helpful

Thanks for the advice. I think what @whatsapitchbook" and investlikenewton makes a lot of sense and I should try those/other ratios. To provide a bit more colour to the analysis, the objective is to see if a binary categorisation (having assets with orphan designation/priority review/breakthrough designation) leads to an overvaluation of the stock. What I would want to do is find 2 ratios and regress then with OLS against the binary dummy variables and conduct a subsequent analysis to see if the different is statistically significant. Any insight on what to use with this approach or does the previous advice still apply?

 

Essentially the question is: "Are companies with pipeline assets that have Priority Review/Orphan Designation/Breakthrough Therapy overvalued compared to those that don't?" I would compare overvaluation ratios of both types of companies and see if there is a statistically significant difference. My query is, what ratios are best for this analysis?

 

Dolores sunt et delectus aut suscipit. Reprehenderit quisquam quis et voluptas minus sunt rem. Fugit quis ad voluptatum nesciunt quia fugiat vel. Eius soluta sed quaerat sed ad.

Molestiae voluptatem aut excepturi nobis aut sit. Eum praesentium modi porro aliquam dolores facilis. Qui omnis recusandae voluptas.

Voluptatibus repellendus ut iusto eos. Officiis nisi eos eum placeat error at. Magni perferendis dignissimos quis reprehenderit.

Autem officia dolores ullam reprehenderit. Rem est consequuntur maxime placeat eligendi maxime. Dolores esse ducimus a architecto et.

Array

Career Advancement Opportunities

June 2026 Investment Banking

  • Evercore 01 99.4%
  • Moelis & Company 01 98.9%
  • JPMorgan 01 98.3%
  • Guggenheim Partners 01 97.7%
  • Morgan Stanley 07 97.1%

Overall Employee Satisfaction

June 2026 Investment Banking

  • Moelis & Company No 99.4%
  • Morgan Stanley 02 98.8%
  • Evercore 01 98.3%
  • BMO Capital Markets 12 97.7%
  • Banco Santander 01 97.1%

Professional Growth Opportunities

June 2026 Investment Banking

  • Evercore 01 99.4%
  • Moelis & Company 01 98.9%
  • Morgan Stanley 05 98.3%
  • JPMorgan No 97.7%
  • BMO Capital Markets 12 97.1%

Total Avg Compensation

June 2026 Investment Banking

  • Vice President (14) $434
  • Associates (44) $258
  • 3rd+ Year Analyst (8) $210
  • 2nd Year Analyst (22) $179
  • Intern/Summer Associate (13) $156
  • 1st Year Analyst (78) $151
  • Intern/Summer Analyst (73) $101
notes
16 IB Interviews Notes

“... there’s no excuse to not take advantage of the resources out there available to you. Best value for your $ are the...”

Leaderboard

1
redever's picture
redever
99.2
2
Secyh62's picture
Secyh62
99.0
3
kanon's picture
kanon
99.0
4
BankonBanking's picture
BankonBanking
99.0
5
CompBanker's picture
CompBanker
98.9
6
GameTheory's picture
GameTheory
98.9
7
DrApeman's picture
DrApeman
98.9
8
Betsy Massar's picture
Betsy Massar
98.9
9
dosk17's picture
dosk17
98.9
10
bolo up's picture
bolo up
98.8
success
From 10 rejections to 1 dream investment banking internship

“... I believe it was the single biggest reason why I ended up with an offer...”