M&A decision rule

Hi,

Is there a decision rule to determine if a strategic buyer should buy and merge with another company? Obviously there are factors such as differing cultures and integration difficulties that could determine, but is there a quantitative way? How is it done in practice? Could it be done by doing a combined DCF including a valuation of synergies and look at value created and compare it to IRR on other projects as well as cost of cap?

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